. Kontrolle der Ovulation; Verfahren der Konferenz in Endicott House, Dedham, Massachusetts, 1960 statt. Ovulation - - Verordnung. 92 Charles H. Sawyer und M. Kawakami Absenken des EEG afterreaction Schwelle bis hin zu dem Punkt, an dem eine "spontane" afterreaction aufgetreten. Für einige Stunden danach die Schwelle blieb auf relativ niedrigem Niveau, aber gewöhnlich nur eine spontane afterreaction Eine solche Injektion gefolgt. In diesem besonderen Fall (Abb. 12) das Kaninchen hatte pretreatcd mit Östrogen und einem temporären Zustand der Volt eine iG. CO 15 2 3 4 5 6 7 ZEIT IN STUNDEN NACH DER HCG [
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. Control of ovulation; proceedings of the conference held at Endicott House, Dedham, Massachusetts, 1960. Ovulation -- Regulation. 92 Charles H. Sawyer and M. Kawakami lowering of the EEG afterreaction threshold to the point at which a "spontaneous" afterreaction occurred. For some hours thereafter the threshold remained at relatively low levels but ordinarily only one spontaneous afterreaction followed such an injection. In this particular case (Fig. 12) the rabbit had been pretreatcd with estrogen and a temporary condition of VOLTS a iG. CO 15 2 3 4 5 6 7 TIME IN HOURS AFTER HCG [ HIPP. HYPERACT. VCESV ECV EVC ECV V-VAGINAL STIM., C-COITUS, E-ELECTRIC STIM., S-SPONTANEGUS rr: SPINDLE LiJ BURSTS I [latency —i COITUS L-J REFUSED Fig. 12. Effect of human chorionic gonadotropin (HCG) on EEG thresholds in the estrogen-primed ovariectomized rabbit. In the unprimed castrate rabbit HCG still depresses the EEG afterreaction threshold but the occurrence of estrus and the slight depression in arousal threshold seen here do not occur in the absence of exogenous estrogen. From Kawakami and Sawyer (43). estrus followed HCG treatment, although the arousal threshold was only slightly depressed. In the absence of estrogen neither estrus nor any effect on the arousal threshold was usually seen, although the EEG afterreaction threshold was reduced to the level at which a spontaneous response occurred. The results support the concept of a close relationship between the EEG afterreaction threshold and pituitary activation and indicate that the influence of these hormones on the nervous system, as well as that of the steroids, is one of altering thresholds rather than acting as stimulants per se. EFFECTS OF THE NEW PROGESTOGENS Some of the newer progestational compounds have been reported to have very prolonged actions (46) and to be strongly inhibitory to ovulation (47). Their effects on the two thresholds were naturally of considerable interest.. Please note that these i
