. Die biologische Bulletin. Biologie; Zoologie; Biologie; Meeresbiologie. Zellbiologie 247. 40 80 120 [LPS | (ng/ml) Abbildung 1. Stimulation der exocytmis der Substrat-verbundenen, kultivierte Limulus amehoi MC h a/gal LPS. (Vor der Exposition sind die Zellen auf der Oberfläche Mitte abgeflacht ohsen behalten ihre sekretorischen Granula, hieh sind "ahle wie die kleine, kugelförmige Vesikel, pack das zytoplasma in der Umgebung des Kerns. ≪Bl Thim min nach Exposition gegenüber 30 jj.g/ml Algen LPS. Alle Substrat befestigter Zellen degranulated haben. Tlie abgeflachten Zellen große interne Lücken, die die Si Zeigen

• Bildanbieter: Library Book Collection / Alamy Stock Foto
• Bild-ID: RHG9PM
• Dateigröße: 7,2 MB (359,4 KB Komprimierter Download)
• Freigaben (Releases): Model - nein | Eigentum - nein
• Format: 1034 x 2417 px | 17,5 x 40,9 cm | 6,9 x 16,1 inches | 150dpi

Weitere Informationen

Dieses Bild ist ein gemeinfreies Bild. Dies bedeutet, dass entweder das Urheberrecht dafür abgelaufen ist oder der Inhaber des Bildes auf sein Urheberrecht verzichtet hat. Alamy berechnet Ihnen eine Gebühr für den Zugriff auf die hochauflösende Kopie des Bildes.

Dieses Bild kann kleinere Mängel aufweisen, da es sich um ein historisches Bild oder ein Reportagebild handel

. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. CELL BIOLOGY 247. 40 80 120 [LPS| (ng/ml) Figure 1. Stimulation of exocytmis of substratum-attached, cultured Limulus amehoi MC h a/gal LPS. (At Prior to exposure, the cells are flattened on the culture surface mid retain their secretory granule*, hieh are ohsen'ahle as the small spherical vesicles that pack the cytoplasm surrounding the nucleus. <Bl Thim min after exposure to 30 jj.g/ml algal LPS. all of the substrate-attached cells have degranulated. Tlie flattened cells show large internal lacunae, which are the sites of fusion of the membranes of the secretory granules with the plasma membrane. Tile contracted shinv cells in {B} are situated above the focal plane of the substratum-attached cells. Tliese are full granulated hlctod e~ells that have separated from the culture surface aiul are now migrating on the surface of the coagiilin clot fonned from materials secreted by the substrate-attached cells. Cells that have lost their attachment to the solid culture sulntrutum arc refractory to stimulation by bacterial LPS (2) and, as sliown here, to a/gal LPS. (C) Tlie response to a/gal LPS occurs more rapidly at higher concentrations of the agonist and requires about 10 times more LPS than does the response to bacterial LPS. Limulus amebocytes generate eicosanoid metabolites (5). The eicosanoids—oxygenated metabolites of the C20 polyunsaturated fatty acids, 20:3n-6. 2():4n-6. and 20:5n-3—operate as second messengers in activating cellular defense reactions to bacterial infection in insects. Exposure of blood cells to the eicosanoid biosynthesis inhibitor naproxin. an inhibitor of cyclooxygenase. abolished the LPS-induced nodulation response by the blood cells of the beetle, Zopliohux (6). Consistent with a role for the eico- sanoids in signaling in the amebocyte, naproxin (1 mM) inhibited the exocytosis response of the cultured Limulus amebocyte both to algal and to bacterial LPS. The

Stockbilder mithilfe von Tags suchen

• booksubjectzoology
• buchautorilliefrankrat
• buchsubjektbiologie